menstrual pain

Matricaria recutita


(In territories with significant traditional TRAMIL use)

 Colombia: manzanilla
 Guatemala: manzanilla
 Honduras: manzanilla

Significant uses found by the TRAMIL surveys

  leaf and flower, infusion, orally4

Recommandations
Preparation and posology
References

According to published and other information:

Use for colic, diarrhea, stomach pain and expulsion of placenta is classified as REC, based on the significant traditional use documented in the TRAMIL surveys, and on available published scientific information.

For diarrhea, the use of this plant can be considered complementary to oral re-hydration therapy.

Should there be a notable worsening of the patient’s condition, or should the colic, diarrhea or stomach pain last more than 3 days, seek medical attention.

The pollen is potentially allergenic and may induce reactions of hypersensitivity in susceptible individuals or those with prior allergy to Asteraceae (esp. ragweed and Chrysanthemum).

 

For menstrual pain and stomach pain:

Prepare an infusion adding 250 mL (1 cup) of boiling water to 3 grams of dried flower. Cover pot, leave to settle for 5-10 minutes and filter.  Drink one cup between meals, 3-4 times a day32-33.

There is no available information about preparation and dosage of the decoction of the entire plant, the infusion of the leaf, or the infusion of the leaf and flower, other than that referred to by traditional use.

1 RAUSCHERT S, 1974 Nomenklatorische Probleme in der Gattung Matricaria L.

Folia Geobot Phytotax Praha 9:249-260.

2 LAGOS-WITTE S, 1988-89, 1996 Encuesta TRAMIL. Laboratorio de Histología Vegetal y Etnobotánica, Dep. de Biología, Universidad Nacional Autónoma de Honduras UNAH, Tegucigalpa, Honduras.

3 GOMEZ H, GAITAN R, DIAZ F, 2003 Encuesta TRAMIL (Norte del departamento de Bolívar). Grupo de Productos Naturales, Facultad de Ciencias Químicas y Farmacéuticas. Universidad de Cartagena, Cartagena de Indias, Colombia.

4 GIRON L, 1988 Encuesta TRAMIL (Costa atlántica). Centro Mesoamericano de Tecnología CEMAT, Guatemala, Guatemala.

5 FRANZ C, WICKEL I, 1980 Contribution to the heredity of bisaboloids in Chamomilla recutita. (abstract). Planta Med 39:287-288.

6 SALAMON I, 1992 Production of chamomile, Chamomilla recutita (L.) Rauschert, in Slovakia. J Herbs Spices Med Plants 1(1/2):37-45.

7 MANCHENO MN, 1987 La manzanilla dentro del plan terapéutico de tratamiento de la enfermedad diarreica aguda del Ministerio de Salud. Nicaragua. Rescate de la Medicina Popular Tradicional.

8 MERICLI AH, 1990 The lypophilic compounds of a Turkish Matricaria chamomilla variety with no chamazulene in the volatile oil. Int J Crude Drug Res 28(2):145-147.

9 TOPOLOV V, GABROLOV M, YANKOLOV J, 1983 Plantas medicinales and fitoterapia (Bilki and Bilcosvirane). Plovdiv, Bulgaria: Ed. Jristo G. Danov.

10 MORON F, FURONES J, PINEDO Z, 1996 Actividad espasmolítica del extracto fluído de Matricaria recutita (Manzanilla) en órganos aislados. Rev Cubana Plant Med 1(1):19-24.

11 CAMBAR P, 1992 Efectos broncopulmonares de los extractos acuosos de flores de Matricaria chamomilla L. (Manzanilla) en conejos. Informe TRAMIL. Unidad de Farmacología, Facultad de Ciencias Médicas, Universidad Nacional Autónoma de Honduras UNAH, Tegucigalpa, Honduras.

12 ABDUL-GHANI AS, EL-LATI SG, SACAAN AI, SULEIMAN MS, AMIN RM, 1987 Anticonvulsant effects of some Arab medicinal plants. Int J Crude Drug Res 25(1):39-43.

13 HOERHAMMER L, 1962 Flavone concentration of medicinal plants with regard to their spasmolytic action. Congr Sci Farm Conf Commun 21st Pisa 1961(21):578-588.

14 JAKOVLEV V, ISAAC O, FLASKAMP E, 1983 Pharmacologische Untersuchungen von Kamillen-Inhaltsstoffen. VI. Untersuchungen zur antiphlogistiche Wirkung von Chamazulen und Matricin. Planta Med 49:67-73.

15 YAMAZAKI M, SHIROTA H, 1981 Application of experimental stress ulcer test in mice for the survey of neurotropic naturally occurring drug materials. Shoyakugaku Zasshi 35:96-102.

16 GERSHEBIN LL, 1977 Regeneration of rat liver in the presence of essential oils and their components. Food Cosmet Toxicol 15(3):173-182.

17 ITOKAWA H, MIHASHI S, WATANABE K, NATSUMOTO H, HAMANAKA T, 1983 Studies on the constituents of crude drugs having inhibitory activity against contraction of the ileum caused by histamine or barium chloride (I). Screening test for the activity of commercially available crude drugs and the related plant materials. Shoyakugaku Zasshi 37(3):223-228.

18 LESLIE GB, 1978 A pharmacometric evaluation of nine bio-strath herbal remedies. Medita 8(10):3-19.

19 SZELENYI I, ISSAC O, THIEMER K, 1979 Pharmakologische Untersuchungen von Kamillen-inhaltsstoffen. III. Tierexperimentelle Untersuchungen uber die ulkusprotektive Wirkung der Kamille. Planta Med 35:218-227.

20 SHIPOCHLIEV T, 1981 Uterotonic action of extract from a group of medicinal plants. Vett Med Nauki 18(4):94-98.

21 ACHTERRATH-TUCKERMANN U, KUNDE R, FLASKAMP E, ISAAC O, THIEMER K, 1980 Pharmacological investigations with compounds of chamomile. V. Investigations on the spasmolytic effect of compounds of chamomile and Kamillosan on the isolated guinea pig ileum. Planta Med 39(1):38-50.

22 AGGAG ME, YOUSEF RT, 1972 Study of antimicrobial activity of chamomile oil. Planta Med 22(2):140-144.

23 MANN C, STABA E, 1986 The chemistry, pharmacology and commercial formulations of chamomile. In: Herbs, spices and medicinal plants; recent advances in botany, horticulture and pharmacology. Phoenix, USA: Oryxpress 1:235-280.

24 ISAAC O, 1979 Pharmacological investigations with compounds of chamomile I. On the pharmacology of alfa-bisabolol and bisabolol oxides (review). Planta Med 35:118-124.

25 JAKOVLEV V, SCHLICHTEGROLL A, 1969 Antiinflammatory activity of (-)-alpha-bisabolol, an essential component of chamomille oil. Arzneim-Forsch 19:615.

26 AL-HINDAWI M, AL-DEEN I, NABI M, ISMAIL M, 1989 Antiinflamatory activity of some Iraqi plants using intact rats. J Ethnopharmacol 26(2):163-168.

27 LESLIE G, SALMON G, 1979 Repeated dose toxicity studies and reproductive studies on nine bio-strath herbal remedies. Swiss Med 1(1/2):1-3.

28 BENNER MH, LEE HJ, 1973 Anaphylactic reaction to chamomille tea. J Allergy Clin Immunol 52(5):307-308.

29 LEWIS R, TATKEN R, (Eds.), 1980 Registry of toxic effects of chemical substances. Vol. 1. Cincinnati, USA: Nat. Instit. Occupational Health.

30 OPDYKE D, 1974 Monographs on fragrance raw materials. Chamomile oil German and Roman. Food Cosmet Toxicol 12(Suppl.):851-853.

31 ANON (Select Committee on GRAS Substances), 1976 GRAS status of foods and food additives. Washington, USA: Food and Drug Administration, Department of Health and Human Services, Office of the Federal Register National Archives and Records Administration 41, 38644.

32 WICHTL M, 1994 Herbal drugs and phytopharmaceuticals. Stuttgart, Germany: Medpharm GmbH Scientific Publisher.

33 GIRON L, CACERES A, FREIRE V, ALONZO A, SALVADOR L, 1995 Folleto informativo sobre algunas plantas medicinales comúnmente utilizadas por la población Garifuna de Livingston. Guatemala, Guatemala: Programa TRAMIL-Centroamérica/enda-caribe/CONAPLAMED/FARMAYA/CIID. p37.

34 MARTINEZ MJ, MOREJON Z, LOPEZ M, BOUCOURT E, MORON F, 2005 Clases tóxicas agudas (CTA) de decocción de flor seca de Matricaria recutita L. Informe TRAMIL. Laboratorio Central de Farmacología, Facultad de Ciencias Médicas “Dr. Salvador Allende”, La Habana, Cuba.

35 LOPEZ M, MARTINEZ MJ, MOREJON Z, BOUCOURT E, FERRADA C, FUENTES V, MORON F, 2005 Irritabilidad dérmica primaria de una decocción de flor seca de Matricaria recutita L. Informe TRAMIL. Laboratorio Central de Farmacología, Facultad de Medicina “Dr. Salvador Allende”, Cerro, C. Habana, Cuba.

36 GarcIa-GONZÁLEZ M, BolaÑos An, arguedas cr, 2005 Efecto analgésico en ratas, por vía oral,del extracto acuoso (decocción) de la planta entera sin flor de Matricaria recutita dosis única. Informe TRAMIL.PRONAPLAMED. Depto de Fisiología, Escuela de Medicina, Universidad de Costa Rica, San Pedro, Costa Rica.

37 GarcIa-GONZÁLEZ M, Arguedas R, y Fernández A, 2005 Efecto antiinflamatorio en ratas, por vía oral, del extracto acuoso (decocción) de la planta entera sin flor de Matricaria recutita dosis única. Informe TRAMIL.PRONAPLAMED. Depto de Fisiología, Escuela de Medicina, Universidad de Costa Rica, San Pedro, Costa Rica.

Wedelia trilobata


(In territories with significant traditional TRAMIL use)

 Costa Rica: marigold
 Grenada: zeba femme
 Puerto Rico: manzanilla

Significant uses found by the TRAMIL surveys

aerial parts, decoction or infusion, orally2

Recommandations
Preparation and posology
References

According to published and other information:

Use for bronchitis is classified as REC, based on the significant traditional use documented in the TRAMIL surveys, toxicity studies, scientific validation and available published scientific information.

Uses for menstrual pain and vomiting are classified as REC, based on the significant traditional use (OMS/WHO)4 documented in the TRAMIL surveys.

For bronchitis, menstrual pain and vomiting:

There is no available information establishing a means of preparation and dosage other than that referred to by traditional use.

Any medicinal preparation must be preserved cold and used within the 24 hours.

1 OCAMPO R, 1988 Encuesta TRAMIL (Costa atlántica), Instituto de Desarrollo Agrario, Universidad de Costa Rica, San José, Costa Rica.

2 MARCELLE G, 1996 TRAMIL survey. Produce chemist laboratory, Ministry of Agriculture, St. George's, Grenada.

3 BENEDETTI MD, 1994 Encuesta TRAMIL. Universidad de Puerto Rico, Mayagüez, Puerto Rico.

4 WHO, 1991 Guidelines for the assessment of herbal medicines. WHO/TRM/91.4. Programme on Traditional Medicines, WHO, Geneva, Switzerland.

5 BOHLMANN F, ZIESCHE J, KING RM, ROBINSON H, 1981 Naturally occurring terpene derivatives. Part 300. Eudesmanolides and diterpenes from Wedelia trilobata and an ent-kaurenic acid derivative from Aspilia parvifolia. Phytochemistry 20(4):751-756.

6 BOHLMANN F, NGO LE VAN, 1977 Naturally occurring terpene derivatives. 97. New kaurene derivatives from Wedelia species. Phytochemistry 16:579-581.

7 CRAVEIRO AA, MATOS FJA, ALENCAR JW, MACHADO MIL, KRUSH A, SILVA MGV, 1993 Volatile constituents of two Wedelia species. J Essent Oil Res 5(4):439-441.

8 KOHEIL MA, 2000 Study of the essential oil of flower-heads of Wedelia trilobata (L.) Hitch. Al-Azhar J Pharm Sci 26:288-293.

9 CACERES A, GONZALEZ S, GIRON L, 1998 Demostración de la actividad antimicrobiana de plantas TRAMIL en base a los usos populares en la cuenca del Caribe. Laboratorio de productos fitofarmacéuticos Farmaya y Facultad de Ciencias Químicas y Farmacia, Universidad de San Carlos, Guatemala, Guatemala.

10 CACERES A, GONZALEZ S, GIRON L, 2000 Demostración de la actividad antimicrobiana de plantas TRAMIL en base a los usos populares en la cuenca del Caribe. Laboratorio de productos fitofarmacéuticos Farmaya y Facultad de Ciencias Químicas y Farmacia, Universidad de San Carlos, Guatemala, Guatemala.

11GarcIa GM, Coto MT, GonzAlez CS, Pazos L, 1999 Actividad bronquial del extracto acuoso de planta entera fresca de Wedelia trilobata. Informe TRAMIL. Laboratorio de Ensayos Biológicos LEBI, Escuela de Medicina, Universidad de Costa Rica, San Pedro, Costa Rica.

12 PAZOS L, COTO T, GONZALEZ S, QUIROS S, 2003 Tránsito intestinal, en ratones, del extracto acuoso de hojas frescas de Wedelia trilobata. Informe TRAMIL. Laboratorio de Ensayos Biológicos, Universidad de Costa Rica, San Pedro, Costa Rica.

13 GarcIa GM, Coto MT, GonzAlez CS, OCAMPO R, Pazos L, 2001 Velocidad del tránsito intestinal en ratones, del extracto acuoso de brotes frescos de Wedelia trilobata. Informe TRAMIL. Laboratorio de Ensayos Biológicos LEBI, Escuela de Medicina, Universidad de Costa Rica, San Pedro, Costa Rica.

14 HERRERA J, 1992 Determinación de parámetros farmacológicos usados en medicina tradicional popular en la Cuenca del Caribe. Departamento de Farmacología, Facultad de Salud, Universidad del Valle, Cali, Colombia.

15 GOH CL, 1986 Contact sensitivity to Wedelia trilobata. Contact Dermatitis 14(2):126.