cutaneous ulcers

Chenopodium ambrosioides


(In territories with significant traditional TRAMIL use)

  • Quintana Roo : apazote
  • Quintana Roo : epazote
  • Colombia : paico
  • Colombia : yerba santa
  • Dominica : wormweed
  • Dominican Republic : apazote, epazote
  • Guatemala : epazote
  • Guatemala : apazote
  • Honduras : epazote
  • Honduras : apazote
  • Haiti : feuilles à vers
  • Haiti : simen-kontra
  • Martinique : zèb avè
  • Martinique : herbe à vers
  • Martinique : simen-kontra
  • Panama : paico
  • Venezuela : pazote

Significant uses found by the TRAMIL surveys

  aerial parts, crushed, applied locally4

Recommandations
Preparation and posology
References

According to published and other information:

Use for diarrhea, stomach pain and intestinal parasites, is classified as REC, based on the significant traditional use documented in the TRAMIL surveys, and on available published scientific information.

In no case should the specified manner of preparation and dosage be altered.

Should there be a notable worsening of the patient’s condition, or should the diarrhea or stomach pain last more than 3 days, or more than 2 days in children over 5 years old, medical attention should be sought.

For diarrhea, this resource is considered complementary to oral re-hydration therapy.

Use for diarrhea, stomach pain and intestinal parasites is recommended only when disorder is caused by ascaris, pinworms and hookworms; not for other types of diarrhoea, stomach pain or other intestinal parasites.

Use is contraindicated in individuals with hepatic disorders, renal insufficiency14, weakened individuals and the elderly.

Not for use by women during pregnancy, as it may be abortifacient, or during breast feeding or by children under 5 years old.

Use for skin ulcer is classified as REC, based on the significant traditional use documented in the TRAMIL surveys and skin toxicity assays.

Should there be a notable worsening of the patient’s condition, or should the skin ulcer last more than 5 days, medical attention should be sought for.

In topical application, strict hygiene measures should be observed in order to avoid contamination or additional infection.

For intestinal parasites, diarrhea and stomach pain caused by parasites:

prepare a decoction or infusion with 7 grams of aerial parts (leaf, flower, stem) in 300 mL (more than 1 cup) of water.  For decoction, boil for at least 10 minutes in a covered pot; for infusion, add boiling water to 7 grams of aerial parts, cover and leave to cool down during 10 minutes.  Strain and drink 1 cup (250 mL) for adults, 1/2 cup (125 mL) for people weighing 35 kg, and 1/3 cup (80 mL) for children over 5 years.  Drink once a day only for 3 consecutive days46 and do not repeat treatment within six months.

Taking a saline laxative is recommended (e.g. magnesium sulfate) after the last intake; however, no oily purgatives should be taken14.

For skin ulcer:

Wash the injury with purified water and soap.  Wash the aerial plant parts properly, press or crush, and apply to affected area.  Cover with a clean cloth and replace twice a day.

1 GIRON L, 1988 Encuesta TRAMIL (Costa atlántica). Centro Mesoamericano de Tecnología CEMAT, Guatemala, Guatemala.

2 DELENS M, 1990-92 Encuesta TRAMIL. Centro de Estudios Sociales y Acción Popular CESAP, Caracas, Venezuela.

3 CHARLES C, 1988 TRAMIL survey. Movement for Cultural Awareness MCA, Roseau, Dominica.

4 WENIGER B, 1987-88 Encuesta TRAMIL. enda-caribe, Santo Domingo, Rep. Dominicana.

5 HERRERA J,1994 Encuesta TRAMIL (Costa atlántica). Laboratorio de fitofarmacología, Departamento de Farmacología, Facultad de Salud, Universidad del Valle, Cali, Colombia.

6 MENDEZ M, MEDINA ML, DURAN R, 1996 Encuesta TRAMIL en Quintana Roo. Unidad de recursos naturales, Centro de Investigación Científica de Yucatán CICY, Mérida, México.

7 WENIGER B, ROUZIER M, 1986 Enquête TRAMIL. Service Oecuménique d'Entraide SOE, Port au Prince, Haïti.

8 LAGOS-WITTE S, 1988-89, 1996 Encuesta TRAMIL. Laboratorio de Histología Vegetal y Etnobotánica, Departamento de Biología, Universidad Nacional Autónoma de Honduras UNAH, Tegucigalpa, Honduras.

9 LONGUEFOSSE JL, NOSSIN E, 1990-95 Enquête TRAMIL. Association pour la valorisation des plantes médicinales de la Caraïbe AVPMC, Fort de France, Martinique.

10 SOTOMAYOR U, RUEDA R, 1990 Encuesta TRAMIL. Centro nacional de la medicina popular tradicional CNMPT, Ministerio de Salud, Estelí, Nicaragua.

11 SolIs PN, Espinosa A, De Gracia J, Martínez L, Gupta MP, 2003 Encuesta TRAMIL (Ngöbe-Buglé). Centro de Investigaciones Farmacognósticas de la Flora Panameña, Facultad de Farmacia, Universidad de Panamá, Panamá, Panamá.

12 SolIs PN, Espinosa A, De Gracia J, Martínez L, Gupta MP, 2003 Encuesta TRAMIL (Emberá-Wounaann). Centro de Investigaciones Farmacognósticas de la Flora Panameña, Facultad de Farmacia, Universidad de Panamá, Panamá, Panamá.

13 GOMEZ H, GAITAN R, DIAZ F, 2003 Encuesta TRAMIL (Norte del departamento de Bolívar). Grupo de Productos Naturales, Facultad de Ciencias Químicas y Farmacéuticas. Universidad de Cartagena, Cartagena de Indias, Colombia.

14 CANIGUERAL S, VILA R, RISCO E, PEREZ F, PORTILLO A, FREIXA B, MILO B, VANACLOCHA B, RIOS JL, MORALES MA, ALONSO JR, BACHILLER LI, PERIS JB, STUBING G, 2002 Quenopodio. Vademecum de Fitoterapia, Barcelona, España, Editorial Masson. Nov.20,2003. URL: http://www.masson.es/book/fitoterapia.html

15 BOURGEOIS P, JOSEPH H, SAVARY H, 1989 Détermination d'huiles essentielles et dosage de l'ascaridole dans Chenopodium ambrosioides. Rapport TRAMIL. Laboratoire de phytochimie, Faculté des Sciences, Université des Antilles et de la Guyane UAG, Pointe à Pitre, Guadeloupe.

16 TAKEMOTO T, NAKAJIMA T, 1957 Study of the essential oils of Chenopodium ambrosioides. V. On the structure of aritasone. Yakugaru Zasshi 77:1157-1158.

17 BAUER L, BRASIL E, SILVA GA, 1973 Essential oils of Chenopodium ambrosioides and Schinus terebenthifolia from Rio Grande do Sul. Rev Brasil Farm 54:240.

18 ARISAWA M, MINABE N, SAEKI R, TAKAKUWA T, NAKAOKI T, 1971 Studies on unutilized resources. V. The components of the flavonoids in Chenopodium genus plants. Yagugaku Zasshi 91:522.

19 JAIN N, LAM MS, KAMIL M, ILYAS M, NIWA M, SAKAE A, 1990 Two flavonol glycosides fromChenopodium ambrosioides.Phytochemistry 29(12):3988-3991.

20 DUKE JA, ATCHLEY AA, 1986 Handbook of proximate analysis tables of higher plants. Boca Raton, USA: CRC Press. p41.

21 CAMBAR P, 1988 Prevención de la producción de úlceras gástricas experimentales por algunos extractos de plantas. Informe TRAMIL. Unidad de Farmacología, Facultad de Ciencias Médicas, Universidad Nacional Autónoma de Honduras, Tegucigalpa, Honduras.

22 DESTA B, 1993 Ethiopian traditional herbal drugs. Part II: Antimicrobial activity of 63 medicinal plants. J Ethnopharmacol 39(2):129-139.

23SAUVAIN M, MORETTI C, MUÑOZ V, 1990 Pruebas in vivo para paludismo realizadas en Bolivia sobre varias plantas TRAMIL. ORSTOM, Universidad Mayor de San Simón, La Paz, Bolivia.

24 MISRA P, PAL N, GURU P, katiyar JC, TANDON JS, 1991 Antimalarial activity of traditional plants against erythrocytic stages of Plasmodium berghei. Int J Pharmacog29(1):19-23.

25 ROSS SA, EL-KELTAWI NE, MEGALLA SE, 1980 Antimicrobial activity of some Egyptian aromatic plants. Fitoterapia51:201-205.

26 BUTZ LN, LA LANDE JR, 1937 Antihelmintics II. A comparison of certain ozonides, Chenopodium oil and diheptanol peroxide. J Am Pharm Assoc 26:114.

27 BLISS AR, 1925 A pharmacodynamic study on the antihelmintic properties of two oils of Chenopodium. J Am Pharm Assoc14:93.

28 FERNAN-NUÑEZ M, 1927 A contribution of helmintic therapy. J Amer Med Assoc88:903.

29 KISHORE N, DUBEY NK, SINGH SK, DIXIT SN, 1981 Fungitoxicity of some volatile natural products against human pathogenic fungi. Indian Perf 25(3/4):1-3.

30 TENG X, 1980 Development of natural products as antimalarial agents. Proc US-China Pharmacology Symp:137-141.

31 KAPADIA GJ, CHUNG EB, GHOSH B, SHUKLA YN, BASAK SP, MORTON JF, PRADHAN SN, 1978 Carcinogenicity of some folk medicinal herbs in rats. J Nat Cancer Inst60:683-686.

32 SALAN W, LIVINGSTONE AE, 1916 Experiments with oil of Chenopodium and cardiac stimulants on the isolated frog heart. Amer J Physiol 41:21.

33 SALAN W, LIVINGSTONE AE, 1915 Experiments with oil of Chenopodium on circulation and respiration. Amer J Physiol38:67.

34 SALAN W, MITCHELL C, 1915 Influence of oil of Chenopodium on intestinal contractility. Amer J Physiol39:37.

35 KLIKS MM, 1985 Studies on the traditional herbal antihelmintic Chenopodium ambrosioides L.: ethnopharmacological evaluation and clinical field trials. Soc Sci Med 21(8):879-886.

36 feroz h, khare ak, srivastava mc, 1982 Review of scientific studies on anthelmintics from plants.J Sci Res Pl Med3:6-12.

37 GONZALEZ A, 1990 Evaluación de la toxicidad dérmica de plantas TRAMIL en conejos. Centro Nacional de Salud Animal, La Habana, Cuba. TRAMIL III, La Habana, Cuba, MINSAP/enda-caribe.

38 OPDYKE DLJ, 1976 Monographs on fragance raw materials. Chenopodium oil. Food Chem Toxicol 14:713-715.

39 BHAKUNI OS, DHAR ML, DHAR MM, DHAWAN BN, MEHROTRA BN, 1969 Screening of Indian plants for biological activity. Part II. Indian J Exp Biol 7:250-262.

40 MOLE A, 1952 Acute fatal poisoning with Chenopodium oil. Folia Med (Naples) 35:955.

41 WOLF IJ, 1932 Fatal poisoning with oil of Chenopodium in a negro child with sickle-cell anemia. Arch Pediatr52:126.

42 CONTRERAS AA, ZOLLA C, 1982 Plantas tóxicas de México.México, México: Instituto Mexicano del Seguro Social.

43 JELLIFFE DB, 1951 Oil of Chenopodium in the treatment of ascariasis. Report of 3 cases of fatal liver damage in African patients. J Trop Med Hyg54:143.

44 MELE A, 1952 Acute poisoning with Chenopodium oil. Folia Med35:955.

45 ANDRIEN J, PARMENTIER PD, COMPERE J, BOUNAMEAUX Y, 1971 Study on Chenopodium oil encephalitis. Three fatal cases. A Soc Belge Med Trop51:299.

46DELENS M, Ed., 2000 Cuaderno de Fitoterapia Clínica (Afecciones respiratorias y digestivas). Mérida, Venezuela: CONAPLAMED. p151.

47 LOPEZ M, MARTINEZ MJ, MOREJON Z, BOUCOURT E, FERRADA C, FUENTES V, MORON F, 2005 Irritabilidad dérmica primaria de una decocción de hoja fresca de Chenopodium ambrosioides L. Informe TRAMIL. Laboratorio Central de Farmacología, Facultad de Medicina “Dr. Salvador Allende”, Cerro, C. Habana, Cuba.

48 LOPEZ M, MARTINEZ MJ, MOREJON Z, BOUCOURT E, FERRADA C, FUENTES V, MORON F, 2005 Irritabilidad dérmica primaria hoja fresca machacada de Chenopodium ambrosioides L. Informe TRAMIL. Laboratorio Central de Farmacología, Facultad de Medicina “Dr. Salvador Allende”, Cerro, C. Habana, Cuba.

49 DELAIGUE J, 2005 TRAMIL survey. UAG & PRDI, Tobago House of Assembly, Scarborough, Tobago.

50 Zambrano LE, 2007 Encuesta TRAMIL en Guareguare, Miranda. UCV, Caracas, Venezuela.

51 PAZOS L, COTO T, CAIZA F, 2009

Toxicidad oral aguda, dosis repetida, en ratón, partes aéreas de Chenopodium ambrosioides. Informe TRAMIL. Laboratorio de Ensayos Biológicos, LEBi, Universidad de Costa Rica, San Pedro, Costa Rica.

52 LOPEZ DE GUIMARAES D, NEYRA LLANOS RS, ROMERO ACEVEDO JH, 2001 Ascariasis; comparación de la eficacia terapéutica entre paico y albendazol en niños de Huaraz. Rev Gastroenterol Peru 21(3):212-219.

53 MACDONALD D, VANCREY K, HARRISON P, RANGACHARI PK, ROSENFELD J, WARREN C, SORGER G, 2004 Ascaridole-less infusions of Chenopodium ambrosioides contain a nematocide(s) that is(are) not toxic to mammalian smooth muscle. J Ethnopharmacol 92:215–221.

54 GADANOA AB, GURNI AA, CARBALLO MA, 2006 Argentine folk medicine: Genotoxic effects of Chenopodiaceae family. J Ethnopharmacol 103:246–251.

55 BOULOGNE I, 2009          

Enquête TRAMIL, (Terre-de-Bas et Terre-de-Haut) Les Saintes, UAG, Guadeloupe.

Eupatorium odoratum


(In territories with significant traditional TRAMIL use)

  • Dominican Republic : rompezaragüey

Significant uses found by the TRAMIL surveys

  leaf, dried in fire (faded), applied locally1

Recommandations
Preparation and posology
References

According to published and other information:

External use for furuncles and skin ulcer is classified as REC, based on the significant traditional use (OMS/WHO)4 documented in the TRAMIL surveys.

For topical application, strict hygienic measures should be observed in order to avoid contamination or additional infection.

Should there be a notable worsening of the patient’s condition, or should furuncles or skin ulcer last for more than 5 days, seek medical attention.

Not for use during pregnancy, during lactation or by children under 5 years old.

For furuncles and skin ulcer:

Wash the affected area with boiled water and soap.  Wash leaf thoroughly, warm it slightly over a fire, take 5-10 grams of this vegetal material and apply topically either directly or mixed with animal fat.  Cover with a pad or with clean cloth and replace twice a day.

1 GERMOSEN-ROBINEAU L, GERONIMO M, AMPARO C, 1984 Encuesta TRAMIL. enda-caribe, Santo Domingo, Rep. Dominicana.

2 WHO, 1991 Guidelines for the assessment of herbal medicines. WHO/TRM/91.4. Programme on Traditional Medicines, WHO, Geneva, Switzerland.

3 BOSE P, CHAKRABARTI D, CHAKRAVARTI S, DUTTA S, BARVA A, 1973 Flavonoid constituents ofEupatorium odoratum. Phytochemistry12(3):667-668.

4 ARENE E, PETTIT G, ODE R, 1978 The isolation of isosakuranetin methyl ether from Eupatorium odoratum. Lloydia 41:68-70.

5 FARNSWORTH N, CORDELL GA, KAAS CJ, 1980 What is odoratin?. J Pharm Sci 69(9):1107.

6 METWALLY A, EKEJIUBA E, 1981 Methoxylated flavonols and flavanones fromEupatorium odoratum. Planta Med 42:403-405.

7 HAI M, SAHA K, AHMAD M, 1995 Chemical constituents ofEupatorium odoratum Linn (Compositae). J Bangladesh Chem Soc 8(2):139-142.

8 AHMAD M, NABI M, 1967 Chemical investigations on the leaves of Eupatorium odoratum. Sci Res 4:154-157.

9 TALAPATRA SK, BHAR DS, TALAPATRA B, 1977 Terpenoids and related compounds : Part XIII. Epoxylupeol, a new triterpenoid from Eupatorium odoratum. Indian J Chem 15B(9):806-807.

10 IWU M, CHIORI C, 1984 Antimicrobial activity of Eupatorium odoratum extracts. Fitoterapia 55(6)354-356.

11 BOSE P, CHAKRABARTI P, CHAKRAVARTI S, DUTTA SP, BARUA AK, 1974 Chemical examination of the leaves ofEupatorium odoratum. Trans Bose Res Inst Calcutta 37(1-2):25-30.

12 INYA-AGHA S, OGUNTIMEIN B, SOFOWORA A, BENJAMIN T, 1987 Phytochemical and antibacterial studies on the essential oil of Eupatorium odoratum. Int J Crude Drug Res 25(1):49-52.

13 NWOKOLO E, 1987 Leaf meals of Siam weed Eupatorium odoratum L. as nutrient source in poultry diet. Nutr Rep Int 36(4):819-826.

14 LE GRAND A, WONDERGEM PA, 1986 Activités antimicrobiennes et études bibliographiques de la toxicologie de dix plantes médicinales de la Caraïbe. Rapport TRAMIL. Dép. de Pharmacognosie, Universités de Groningen & Leyden, Hollande.

15 GUPTA M, ESPOSITO AVELLA M, 1988 Evaluación química y farmacológica de algunas plantas medicinales de TRAMIL. Centro de Investigaciones Farmacognósticas de la Flora Panameña CIFLORPAN, Facultad de Farmacia, Universidad de Panamá, Panamá, Panamá.

16 JOYEUX M, FLEURENTIN J, DORFMAN P, MONTIER F, 1988 Recherche d'une activité hépatotrope et antiradicalaire de plantes médicinales de la caraïbe. Rapport TRAMIL. Laboratoire de Pharmacognosie, Centre des Sciences pour l'Environnement, Metz, France.

17 FIALLO M, VAZQUEZ TINEO M, 1992 Evaluación in vitro de plantas usadas en afecciones de la piel: Extractos vegetales antimicóticos y antimicrobianos. Informe TRAMIL. CIBIMA, Facultad de Ciencias, Universidad Autónoma UASD, Santo Domingo, Rep. Dominicana.

18 CACERES A, MENENDEZ H, MENDEZ E, COHOBON E, SAMAYAO BE, JAUREGUI E, PERALTA E, CARRILLO G, 1992 Antigonorrhoeal activity of plants used in Guatemala for the treatment of sexually transmitted diseases. J Ethnopharmacol 48(2):85-88.

19 DUKE JA, 1992 Handbook of biologically active phytochemicals and their bioactivities. Boca Raton, USA: CRC Press.

20 FENG PC, HAYNES LJ, MAGNUS KE, PLIMMER JR, SHERRAT HSA, 1962 Pharmacological screening of some West Indian medicinal plants. J Pharm Pharmacol14:556-561.

21 BHAKUNI O, DHAR ML, DHAR MM, DHAWAN BN, MEHROTRA BN, 1969 Screening of Indian plants for biological activity. Part II. Indian J Exp Biol 7(4):250-262.

22 MARTINEZ MJ, LOPEZ M, MOREJON Z, BOUCOURT E, FUENTES V, MORON F, 2000 Toxicidad aguda tópica hojas frescas calentadas de Eupatorium odoratum L. Informe TRAMIL. Laboratorio Central de Farmacología, Facultad de Ciencias Médicas "Dr. Salvador Allende", La Habana, Cuba.