Survey results, specifically regarding the “health problem / plant-part used,” are compared with the existing bibliography and, if necessary, pharmacological, chemical and /or clinical tests (called TRIGs) are undertaken. TRAMIL’s pool of specialists reviews the results of such tests and, taking into account the minimum quality and effectiveness standards, issues a specific recommendation.
In this project, EFFECTIVENESS means effect supported by:
- Significant traditional use as established by the TRAMIL Surveys.
- Results of published pre-clinical and/or clinical pharmacological research, or results of the research conducted by the TRAMIL group, called "TRIGS".
Our methodology requires demonstration of the effectiveness of the plant-part / administration-means combination in solving a health problem. This requirement is a key differentiator of TRAMIL findings, compared to other ethnobotanical or ethnomedical studies that provide for the recording of plant knowledge without regard to therapeutic effectiveness.
MINIMUM QUALITY STANDARDS
- Botanical identification of specimen (with voucher: gatherer /number / herbarium code).
- Plant-part used, free of chemical or biological pollutants.
- Process standardization according to traditional preparation.
- Use of fresh (recently made) preparations, obtained with an aqueous solution (unless otherwise stated), non-preservable.
- Use of hygienic conditions in preparation and administration.
MINIMUM EFFICIENCY AND SAFETY STANDARDS
- Significant traditional use in TRAMIL Surveys.
- Bibliographic evidence of pharmacological activity.
- Pharmacological studies aimed at demonstrating reported activity*.
- Toxicity studies proving compatibility with use (if they are not reported in the literature).
*The absence of positive results is NOT a criterion for disregarding its traditional use. Only a controlled clinical assay on the specific vegetal drug can be considered definitive grounds for inefficiency.