colics

Ambrosia peruviana

(In territories with significant traditional TRAMIL use)

Panama:

  • altamisa

Honduras:

  • altamisa

Dominican Republic:

  • artamisa
Significant uses found by the TRAMIL surveys

fresh leaf and stem, infusion, orally1

Recommendations Preparation and Dosage References

According to available information:

Use for colic, stomach pain and headache is classified as REC, based on the significant traditional use (OMS/WHO)4 documented in the TRAMIL surveys.

Not for use during pregnancy, during lactation or by children under 5 years old.

The pollen deposited on the stem and leaves may cause reactions of hypersensitivity.
Should there be a notable worsening of the patient’s condition, or should the colic or stomach pain last more than 3 days, seek medical attention.

Due to the presence of allergenic pollen in the stem and leaves, wash vegetal material before use.

For colic, stomach pain and headache:

There is no available information establishing a means of preparation and dosage other than that referred to by traditional use.

1 LAGOS-WITTE S, 1988-89, 1996
Encuesta TRAMIL. Laboratorio de Histología Vegetal y Etnobotánica, Departamento de Biología, Universidad Nacional Autónoma de Honduras UNAH, Tegucigalpa, Honduras.

2 GERMOSÉN-ROBINEAU L, GERÓNIMO M, AMPARO C, 1984
Encuesta TRAMIL. enda-caribe, Santo Domingo, Rep. Dominicana.

3 SOLÍS P, CORREA M, GUPTA MP, 1995
Encuesta TRAMIL (Comunidades afro-caribeñas). Centro de Investigaciones Farmacognósticas de la Flora Panameña CIFLORPAN, Facultad de Farmacia, Universidad de Panamá, Panamá, Panamá.

4 SOLÍS PN, VASQUEZ Y, AYALA H, GUPTA MP, 2002
Validación de algunas plantas tramil. Informe TRAMIL. Centro de Investigaciones Farmacognósticas de la Flora Panameña CIFLORPAN, Facultad de Farmacia, Universidad de Panamá, Panamá, Panamá.

5 GOLDSBY G, BURKE BA, 1987
Sesquiterpene lactones and a sesquiterpene diol from Jamaican Ambrosia peruviana. Phytochemistry 26(4):1059-1063.

6 HERZ W, ANDERSON GD, GIBAJA S, RAULAIS D, 1969
Sesquiterpene lactones of some Ambrosia species. Phytochemistry 8(5):877-881.

7 YÁNEZ CA , RIOS N. MORA F, ROJAS L, DÍAZ T, VELASCO J, RIOS N, MELÉNDEZ P, 2011
Composición quimica y actividad antibacteriana del aceite esencial de Ambrosia peruviana Willd. de los llanos venezolanos. Rev Peru Biol 18(2):149-151.

8 SOUZA BRITO A, 1995
Toxicidad aguda - dosis repetidas. Informe TRAMIL. Dep. de Fisiología y Biofísica, Universidad de Campinas, Campinas, Brasil.

9 BUZNEGO MT, LLANIO M, FERNÁNDEZ M, LEÓN N, ACEVEDO M, PÉREZ H, 1998
Perfil neurofarmacológico de la Ambrosia paniculata (Willd) O.E. Schulz (Artemisa). Rev Cubana Plantas Med 3(1):42-45.

10 PAZOS L, COTO T, 2011
Toxicidad oral aguda, dosis repetida, en ratón, hoja de Ambrosia peruviana. Laboratorio de Ensayos Biológicos, LEBi, Universidad de Costa Rica, San Pedro, Costa Rica.

11 PAZOS L, COTO T, CAIZA F, 2009
Irritación dérmica, piel lesionada en conejos, hoja fresca, de Ambrosia peruviana. Informe TRAMIL. Laboratorio de Ensayos Biológicos, LEBi, Universidad de Costa Rica, San Pedro, Costa Rica.

12 PAZOS L, COTO T, CAIZA F, 2009
Irritación dérmica, piel lesionada en conejos, hoja macerada en alcohol 94%, de Ambrosia peruviana. Informe TRAMIL. Laboratorio de Ensayos Biológicos, LEBi, Universidad de Costa Rica, San Pedro, Costa Rica.

Citrus aurantium

(In territories with significant traditional TRAMIL use)

Cuba:

  • naranja agria
  • naranja de babor

Mexico:

  • naranja agria
  • naranja de babor

Puerto Rico:

  • naranja agria
  • naranja de babor

Dominican Republic:

  • naranja agria, naranja de babor

Martinique:

  • oranger amer
  • zowanj anmè

Grenada:

  • sour orange

Haiti:

  • zowanj gospo
  • zowanj si
Significant uses found by the TRAMIL surveys

leaf, decoction or infusion, orally1

Recommendations Preparation and Dosage References

According to published and other information:

Use for colic, conjunctivitis, headache, fever, flu, intestinal parasites and cough is classified as REC, based on the significant traditional use (OMS/WHO)4 documented in the TRAMIL surveys.

In every application in the eyes, strict hygiene measures should be observed in order to avoid contamination or additional infection.  Additionally, contact with any substances that may be irritating to the conjunctiva should be avoided.  There exists the risk of increasing irritation due to the application of Citrus spp juice.

Should there be a notable worsening of the patient’s condition, or should fever last more than 2 days, or should conjunctivitis or headache last more than 3 days, seek medical attention.

Use for diarrhea and flatulence is classified as REC, based on the significant traditional use documented in the TRAMIL surveys, and on available published scientific information.

In the case of diarrhea, the use of this resource can be considered complementary to oral re-hydration therapy.  Should there be a notable worsening of the patient’s condition, or should diarrhea last more than 3 days in adult, or 2 days in children, seek medical attention.

Due to the risk of interaction with cyclosporin, ingestion of the fruit decoction should be avoided by anyone taking this medicine.

The essential oil of the plant can cause reactions of hypersensitivity.

The fruit and the juice of Citrus aurantium are widely used for human consumption and the peel as an industrial source of essential oil.

For colic, headache, fever, flu:

Prepare a decoction or infusion with 10-15 grams (3-5 tender leaves) in 1/2 liter (2 cups) of water.  For decoction, boil for at least 10 minutes in a covered pot; for infusion, add boiling water to 3-5 tender leaves, cover and leave to cool down.  Drink lukewarm, 1 cup 3 times a day1.

For fever:

Prepare a decoction with 1-2 teaspoonfuls (5-10 grams) of fruit peel in 250 mL (1 cup) of water, boil for at least 10 minutes in a covered pot.  Filter, cool down and drink 1 cup 3 times a day33.

For flatulence:

Prepare an infusion, adding 1 liter (4 cups) of boiling water to the peel of half a fruit.  Cover the pot, let it settle for 5-10 minutes and filter.  Drink 1 cup as needed5.

For intestinal parasites:

Prepare a decoction with 8-18 tender leaves in 1/2 liter (2 cups) of water.  Boil for at least 10 minutes in a covered pot.  Leave it to cool down, sweeten with honey and drink lukewarm, 1 cup twice a day1.

For conjunctivitis, diarrhea, flu, cough (juice):

There is no available information establishing a means of preparation and dosage other than that referred to by traditional use.

1 MOREJON Z, LOPEZ M, GARCIA MJ, BOUCOURT E, VICTORIA M, FUENTES V, MORON F, BOULOGNE I, ROBINEAU L, 2009
Encuesta TRAMIL preliminar a grupos de vecinos en los municipios 10 de Octubre, Lisa, Marianao, Habana del Este (Cojímar) en la Ciudad de la Habana. Laboratorio Central de Farmacología, Universidad de Ciencias Médicas de La Habana, Ciudad de La Habana, Cuba.

2 MENDEZ M, MEDINA ML, DURAN R, 1996
Encuesta TRAMIL. Unidad de recursos naturales, Centro de Investigación Científica de Yucatán CICY, Mérida, México.

3 WENIGER B, ROUZIER M, 1986
Enquête TRAMIL. Service Oecuménique d'Entraide SOE, Port au Prince, Haïti.

4 WENIGER B, 1987-88
Encuesta TRAMIL. enda-caribe, Santo Domingo, Rep. Dominicana.

5 GERMOSEN-ROBINEAU L, GERONIMO M, AMPARO C, 1984
Encuesta TRAMIL. enda-caribe, Santo Domingo, Rep. Dominicana.

6 MARCELLE G, 1996
TRAMIL survey. Produce chemist laboratory, Ministry of Agriculture, St George's, Grenada.

7 BENEDETTI MD, 1994
Encuesta TRAMIL. Universidad de Puerto Rico, Mayagüez, Puerto Rico.

8 LONGUEFOSSE JL, NOSSIN E, 1990-95
Enquête TRAMIL. Association pour la valorisation des plantes médicinales de la Caraïbe AVPMC, Fort de France, Martinique.

9 LIN Z, HUA Y, GU Y, 1986
The chemical constituents of the essential oil from the flowers, leaves and peels of Citrus aurantium. Chih Wu Hsueh Pao 28(6):635-640.

10 RIO JAD, BENAVENTE O, CASTILLO J, BORREGO F, 1992
Neodiosmin, a flavone glycoside of Citrus aurantium. Phytochemistry 31(2):723-724.

11 BENNETT RD, MIYAKE M, OZAKI Y, HASEGAWA S, 1991
Limonoid glucosides in Citrus aurantium. Phytochemistry 30(11):3803-3805.

12 WIDMER WW, 1991
Improvements in the quantitation of limonin in Citrus juice by reversed-phase high-performance liquid chromatography. J Agric Food Chem 39(8):1472-1476.

13 HERMAN Z, FONG CH, OU P, HASEGAWA S, 1990
Limonoid glucosides in orange juices by HPLC. J Agric Food Chem 38(9):1860-1861.

14 HOSODA K, NOGUCHI M, KANAYA T, HIGUCHI M, 1990
Studies on the preparation and evaluation of Kijitsu, the immature citrus fruits. III. Relation between diameter of Kijitsu and synephrine content. Yakugaku Zasshi 110(1):82-84.

15 BEZANGER-BEAUQUESNE L, PINKAS M, TORCK M, 1986
Les plantes dans la thérapeutique moderne. 2 éd. Paris, France: Ed. Maloine.

16 WAGNER H, BLADT S, MUNZING-VASITIAN K, 1975
Thin-layer chromatography of bitter principle drugs. Pharm-Ztg 120:1262.

17 DUKE JA, ATCHLEY AA, 1986
Handbook of proximate analysis tables of higher plants. Boca Raton, USA: CRC Press, p45.

18 BOUCOURT E, MARTINEZ M J, MOREJON Z, 2010
Evaluación de la actividad antimicrobiana del zumo del fruto fresco de Citrus aurantium L. Informe TRAMIL. Laboratorio Central de Farmacología, Facultad de Ciencias Médicas “Dr. Salvador Allende”, C. Habana, Cuba.

19 MORON FJ, MOREJON Z, GARCIA AI, LOPEZ M, BOUCOURT E, BACALLAO Y, FUENTES V, 2008
Acción analgésica de la decocción 30% de hojas frescas de Citrus aurantium L. (naranja agria) en ratones. Informe TRAMIL. Laboratorio Central de Farmacología, Facultad de Ciencias Médicas “Dr. Salvador Allende”, Ciudad de La Habana, Cuba.

20 AVIRUTANT W, PONGPAL A, 1983
The antimicrobial activity of some Thai flowers and plants. Mahidol Univ J Pharm Sci 10(3):81-86.

21 CACERES A, GIRON LM, ALVARADO SR, TORRES MF, 1987
Screening of antimicrobial activity of plants popularly used in Guatemala for the treatment of dermatomucosal diseases. J Ethnopharmacol 20(3):223-237.

22 KIM DH, SONG MJ, BAE EA, HAN MJ, 2000
Inhibitory effect of herbal medicines on rotavirus infectivity. Biol Pharm Bull 23(3):356-358.

23 SANKAWA U, 1980
Screening of bioactive compounds in oriental medicinal drugs. Korean J Pharmacog 11:125-132.

24 KINOSHITA T, SAMESHIMA M, SANKAWA U, 1979
Isolation of a sympathomimetic substance from Chinese medicinal drugs originated from Citrus sp. Shoyakugaku Zassmi 33:146-149.

25 YOO JS, JUNG JS, LEE TH, SON KH, SUH HW, SONG DK, KIM YH, 1995
Inhibitory effects of extracts from traditional herbal drugs on 5-hydroxytryptophan-induced diarrhea in mice. Korean J Pharmacog 26(4):355-359.

26 FORSTER HB, NIKLAS H, LUTZ S, 1980
Antispasmodic effects of some medicinal plants. Planta Med 40(4):309-319.

27 IWAMA H, AMAGAYA S, OGIHARA Y, 1986
Effects of five kampohozais on the mitogenic activity of lipopolysaccharide, concanavalin A, phorbol myristate acetate and phytohemagglutinin in vivo. J Ethnopharmacol 18(2):193-204.

28 HIRANO H, TAKASE H, YAMAMOTO K, YANASE T, ABE K, SAITO Y, 1997
The anti-ulcer effects of Aurantii Fructus Immaturus, Aurantii Fructus and the principles in Aurantii Fructus Immaturus. Nat Med 51(3):190-193.

29 AZUMA S, YADA Y, IMOKAWA G, TAZAKI S, SHINHO T, 1996
Skin-lightening cosmetics containing plant extracts and ascorbic acid or placenta extracts. Patent-Japan Kokai Tokyo Koho-08 208,451.

30 AMEER B, WEINTRAUB RA, JOHNSON JV, YOST RA, ROUSEFF RL, 1996
Flavonone absorption after naringin, hesperidin, and Citrus administration. Clin Pharmacol Ther 60(1):34-40.

31 HARTMAN JG, LIMBIRD ILE, Eds., 1996
Goodman & Gilman las bases farmacológicas de la Terapéutica, 9a edición. México, México: McGraw-Hill Editorial. p1670-1671.

32 MARTINEZ MJ, MOREJON Z, LOPEZ M, BOUCOURT E, FUENTES V, MORON F, 2005
Clases tóxicas agudas (CTA) de una infusión de corteza de fruto fresco de Citrus aurantium L. Informe TRAMIL. Laboratorio Central de Farmacología, Facultad de Ciencias Médicas “Dr. Salvador Allende”, La Habana, Cuba.

33 MARTINEZ MJ, MOREJON Z, LOPEZ M, BOUCOURT E, FUENTES V, MORON F, 2005
Clases tóxicas agudas (CTA) de zumo de fruto fresco de Citrus aurantium L. Informe TRAMIL. Laboratorio Central de Farmacología, Facultad de Ciencias Médicas “Dr. Salvador Allende”, La Habana, Cuba.

34 GARCIA-GONZALEZ M, FALLAS LV, 2005
Toxicidad aguda dosis repetida, en ratones, del extracto acuoso (decocción) de las hojas frescas de Citrus aurantium . Informe TRAMIL. PRONAPLAMED. Depto de Fisiología, Escuela de Medicina, Universidad de Costa Rica, San Pedro, Costa Rica.

35 PAZOS L, COTO T, CAIZA F, 2009 Irritación ocular, en conejos, del jugo fresco del fruto de Citrus aurantium. Informe TRAMIL. Laboratorio de Ensayos Biológicos, LEBi, Universidad de Costa Rica, San Pedro, Costa Rica.

36 PENZAK SR, JANN MW, COLD JA, HON YY, DESAI HD, GURLEY BJ, 2001Seville (sour) orange juice: synephrine content and cardiovascular effects in normotensive adults. J Clin Pharmacol 41(10):1059-1063.

37 PARRA AL, YHEBRA RS, SARDINAS IG, BUELA LI, 2001Comparative study of the assay of Artemia salina L. and the estimate of the medium lethal dose (LD50 value) in mice, to determine oral acute toxicity of plant extracts. Phytomedicine 8(5):395-400.

38 CALAPAI G, FIRENZUOLI F, SAITTA A, SQUADRITO F, ARLOTTA MR, COSTANTINO G, INFERRERA G, 1999Antiobesity and cardiovascular toxic effects of Citrus aurantium extracts in the rat: a preliminary report. Fitoterapia 70(6):586-592.

39 HOU YC, HSIU SL, TSAO CW, WANG YH, CHAO PD, 2000
Acute intoxication of cyclosporin caused by coadministration of decoctions of the fruits of Citrus aurantium and the pericarps of Citrus grandis. Planta Med 66(7):653-655.

40 SATO A, 1989
Studies on anti-tumor activity of crude drugs. I. The effects of aqueous extracts of some crude drugs in short term screening test. Yakugaku Zasshi 109(6):407-423.

41 YAMAMOTO H, MIZUTANI T, NOMURA H, 1982
Studies on the mutagenicity of crude drug extracts. I. Yakugaku Zasshi 102(6):596-601.

42 MORIMOTO I, WATANABE F, OSAWA T, OKITSU T, KADA T, 1982
Mutagenicity screening of crude drugs with Bacillus subtilis REC-assay and Salmonella microsome reversion assay. Mutat Res 97(2):81-102.

43 STOHS SJ, PREUSS HG, 2010
The safety of bitter orange (Citrus aurantium) and p-synephrine. HerbalGram 89:34-39.

44 CANIGUERAL S, VILA R, RISCO E, PEREZ F, PORTILLO A, FREIXA B, MILO B, VANACLOCHA B, RIOS JL, MORALES MA, ALONSO JR, BACHILLER LI, PERIS JB, STUBING G, 2002
Citrus aurantium. Vademecum de Fitoterapia, Editorial Masson, Barcelona, España, Jul.20,2002. URL: www.masson.es/book/fitoterapia.html

Matricaria recutita

(In territories with significant traditional TRAMIL use)

Honduras:

  • manzanilla

Guatemala:

  • manzanilla

Colombia:

  • manzanilla
Significant uses found by the TRAMIL surveys

  entire plant, decoction, orally2

Recommendations Preparation and Dosage References

According to published and other information:

Use for colic, diarrhea, stomach pain and expulsion of placenta is classified as REC, based on the significant traditional use documented in the TRAMIL surveys, and on available published scientific information.

For diarrhea, the use of this plant can be considered complementary to oral re-hydration therapy.

Should there be a notable worsening of the patient’s condition, or should the colic, diarrhea or stomach pain last more than 3 days, seek medical attention.

The pollen is potentially allergenic and may induce reactions of hypersensitivity in susceptible individuals or those with prior allergy to Asteraceae (esp. ragweed and Chrysanthemum).

 

For menstrual pain and stomach pain:

Prepare an infusion adding 250 mL (1 cup) of boiling water to 3 grams of dried flower. Cover pot, leave to settle for 5-10 minutes and filter.  Drink one cup between meals, 3-4 times a day32-33.

There is no available information about preparation and dosage of the decoction of the entire plant, the infusion of the leaf, or the infusion of the leaf and flower, other than that referred to by traditional use.

1 RAUSCHERT S, 1974
Nomenklatorische Probleme in der Gattung Matricaria L.
Folia Geobot Phytotax Praha 9:249-260.

2 LAGOS-WITTE S, 1988-89, 1996
Encuesta TRAMIL. Laboratorio de Histología Vegetal y Etnobotánica, Dep. de Biología, Universidad Nacional Autónoma de Honduras UNAH, Tegucigalpa, Honduras.

3 GOMEZ H, GAITAN R, DIAZ F, 2003
Encuesta TRAMIL (Norte del departamento de Bolívar). Grupo de Productos Naturales, Facultad de Ciencias Químicas y Farmacéuticas. Universidad de Cartagena, Cartagena de Indias, Colombia.

4 GIRON L, 1988
Encuesta TRAMIL (Costa atlántica). Centro Mesoamericano de Tecnología CEMAT, Guatemala, Guatemala.

5 FRANZ C, WICKEL I, 1980
Contribution to the heredity of bisaboloids in Chamomilla recutita. (abstract). Planta Med 39:287-288.

6 SALAMON I, 1992
Production of chamomile, Chamomilla recutita (L.) Rauschert, in Slovakia. J Herbs Spices Med Plants 1(1/2):37-45.

7 MANCHENO MN, 1987
La manzanilla dentro del plan terapéutico de tratamiento de la enfermedad diarreica aguda del Ministerio de Salud. Nicaragua. Rescate de la Medicina Popular Tradicional.

8 MERICLI AH, 1990
The lypophilic compounds of a Turkish Matricaria chamomilla variety with no chamazulene in the volatile oil. Int J Crude Drug Res 28(2):145-147.

9 TOPOLOV V, GABROLOV M, YANKOLOV J, 1983
Plantas medicinales and fitoterapia (Bilki and Bilcosvirane). Plovdiv, Bulgaria: Ed. Jristo G. Danov.

10 MORON F, FURONES J, PINEDO Z, 1996
Actividad espasmolítica del extracto fluído de Matricaria recutita (Manzanilla) en órganos aislados. Rev Cubana Plant Med 1(1):19-24.

11 GARCIA-GONZÁLEZ M, BOLAÑOS AN, ARGUEDAS CR, 2005
Efecto analgésico en ratas, por vía oral, del extracto acuoso (decocción) de la planta entera sin flor de Matricaria recutita dosis única. Informe TRAMIL. PRONAPLAMED. Depto de Fisiología, Escuela de Medicina, Universidad de Costa Rica, San Pedro, Costa Rica.

12 GARCIA-GONZÁLEZ M,  ARGUEDAS R, y FERNANDEZ A, 2005
Efecto antiinflamatorio en ratas, por vía oral, del extracto acuoso (decocción) de la planta entera sin flor de Matricaria recutita dosis única. Informe TRAMIL. PRONAPLAMED. Depto de Fisiología, Escuela de Medicina, Universidad de Costa Rica, San Pedro, Costa Rica.

13 ABDUL-GHANI AS, EL-LATI SG, SACAAN AI, SULEIMAN MS, AMIN RM, 1987
Anticonvulsant effects of some Arab medicinal plants. Int J Crude Drug Res 25(1):39-43.

14 HOERHAMMER L, 1962
Flavone concentration of medicinal plants with regard to their spasmolytic action. Congr Sci Farm Conf Commun 21st Pisa 1961(21):578-588.

15 JAKOVLEV V, ISAAC O, FLASKAMP E, 1983
Pharmakologische Untersuchungen von Kamillen-Inhaltsstoffen. VI. Untersuchungen zur antiphlogistichen Wirkung von Chamazulen und Matricin. Planta Med 49(10):67-73.

16 YAMAZAKI M, SHIROTA H, 1981
Application of experimental stress ulcer test in mice for the survey of neurotropic naturally occurring drug materials. Shoyakugaku Zasshi 35:96-102.

17 GERSHEBIN LL, 1977
Regeneration of rat liver in the presence of essential oils and their components. Food Cosmet Toxicol 15(3):173-182.

18 ITOKAWA H, MIHASHI S, WATANABE K, NATSUMOTO H, HAMANAKA T, 1983
Studies on the constituents of crude drugs having inhibitory activity against contraction of the ileum caused by histamine or barium chloride (I). Screening test for the activity of commercially available crude drugs and the related plant materials. Shoyakugaku Zasshi 37(3):223-228.

19 LESLIE GB, 1978
A pharmacometric evaluation of nine bio-strath herbal remedies. Medita 8(10):3-19.

20 SZELENYI I, ISAAC O, THIEMER K, 1979
Pharmakologische Untersuchungen von Kamillen-inhaltsstoffen. III. Tierexperimentelle Untersuchungen über die ulkusprotektive Wirkung der Kamille. Planta Med 35(3):218-227.

21 SHIPOCHLIEV T, 1981
Uterotonic action of extract from a group of medicinal plants. Vett Med Nauki 18(4):94-98.

22 AGGAG ME, YOUSEF RT, 1972
Study of antimicrobial activity of chamomile oil. Planta Med 22(2):140-144.

23 MANN C, STABA E, 1986
The chemistry, pharmacology and commercial formulations of chamomile. In: Herbs, spices and medicinal plants; recent advances in botany, horticulture and pharmacology. Phoenix, USA: Oryxpress 1:235-280.

24 ISAAC O, 1979
Pharmacological investigations with compounds of chamomile I. On the pharmacology of alpha-bisabolol and bisabolol oxides (review). Planta Med 35(2):118-124.

25 ACHTERRATH-TUCKERMANN U, KUNDE R, FLASKAMP E, ISAAC O, THIEMER K, 1980
Pharmacological investigations with compounds of chamomile. V. Investigations on the spasmolytic effect of compounds of chamomile and Kamillosan on the isolated guinea pig ileum. Planta Med 39(1):38-50.

26 MARTINEZ MJ, MOREJON Z, LOPEZ M, BOUCOURT E, MORON F, 2005
Clases tóxicas agudas (CTA) de decocción de flor seca de Matricaria recutita L. Informe TRAMIL. Laboratorio Central de Farmacología, Facultad de Ciencias Médicas “Dr. Salvador Allende”, La Habana, Cuba.

27 JAKOVLEV V, SCHLICHTEGROLL A, 1969
Antiinflammatory activity of (-)-alpha-bisabolol, an essential component of chamomille oil. Arzneim-Forsch 19:615.

28 AL-HINDAWI M, AL-DEEN I, NABI M, ISMAIL M, 1989
Antiinflamatory activity of some Iraqi plants using intact rats. J Ethnopharmacol 26(2):163-168.

29 LESLIE G, SALMON G, 1979
Repeated dose toxicity studies and reproductive studies on nine bio-strath herbal remedies. Swiss Med 1(1/2):1-3.

30 VIZOSO A, RAMOS A, VILLAESCUSA A, DEDALO M, BETANCOUR J, 2000
Evaluación del efecto genotóxico en extractos fluidos de Plantago lanceolata L., (llantén menor) y Matricaria chamomilla L. (manzanilla). Revista cubana de plantas medicinales 5(2):59-63.

31 BENNER MH, LEE HJ, 1973
Anaphylactic reaction to chamomille tea. J Allergy Clin Immunol 52(5):307-308.

32 LEWIS R, TATKEN R, (Eds.), 1980
Registry of toxic effects of chemical substances. Vol. 1. Cincinnati, USA: Nat. Instit. Occupational Health.

33 ANON (Select Committee on GRAS Substances), 1976
GRAS status of foods and food additives. Washington, USA: Food and Drug Administration, Department of Health and Human Services, Office of the Federal Register National Archives and Records Administration 41, 38644.

Tanacetum parthenium

(In territories with significant traditional TRAMIL use)

Guatemala:

  • altamiza
Significant uses found by the TRAMIL surveys

  leaf, infusion, orally1

Recommendations Preparation and Dosage References

According to published and other information:

Uses for stomach pain are classified as REC, based on the significant traditional use (OMS/WHO)3 documented in the TRAMIL surveys.

Should there be a notable worsening of the patient’s condition, or should symptoms persist for more than 3 days, seek medical attention.

Due to the risks of interaction with anticoagulants, the leaf decoction should not be ingested by patients treated with anticoagulants4.

Not for use by pregnant women as it may cause abortion.  Not for use during lactation, or by children under 5 years old.

This plant is used as aperitif19.

For stomach pain:

Add 250 mL of boiling water to 3 grams of leaf and fresh flowers.  Cover pot, leave to settle for 5-10 minutes and filter.  Drink 1 cup 3 times a day21.

Any medicinal preparation must be preserved cold and used within the 24 hours.

The herb is not good-tasting and has some adverse effects.  The recommendation is to take only occasionally, using standardized products4.

1 GIRON L, 1988
Encuesta TRAMIL (Costa atlántica). Centro Mesoamericano de Tecnología CEMAT, Guatemala, Guatemala.

2 ALONSO JR, 1998
Tratado de fitomedicina. Bases clínicas y farmacológicas. Buenos Aires, Argentina: Ed. ISIS S.R.L. p910.

3-19 AWANG DV, 1998                                                                                                                                                                                         Prescribing therapeutic feverfew (Tanacetum parthenium (L.) Schultz Bip., syn. Chrysanthemum parthenium (L.) Bernh.). Integrative Med 1(1):11-13.

4 WILLIAMS CA, HOULT JR, HARBORNE JB, GREENHAM J, EAGLES J, 1995
A biologically active lipophilic flavonol from Tanacetum parthenium. Phytochemistry 38(1):267-270.

5 DOLMAN DM, KNIGHT DW, SALAN U, TOPLIS D, 1992
A quantitative method for the estimation of parthenolide and other sesquiterpene lactones containing alpha-methylene-butyrolactone functions present in feverfew, Tanacetum parthenium. Phytochem Anal 3(1):26-31.

6 BARSBY RW, SALAN U, KNIGHT DW, HOULT JR, 1993
Feverfew and vascular smooth muscle: extracts from fresh and dried plants show opposing pharmacological profiles, dependent upon sesquiterpene lactone content. Planta Med 59(1):20-25.

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