Lantana camara

Scientific name: Lantana camara L.

Synonym: Lantana armata Schauer

Botanical family: VERBENACEAE

Vernacular names

(In territories with significant traditional TRAMIL use)

Venezuela:

cariaquillo
cariaquito

Trinidad and Tobago:

graterwood
guanatel
kayakeet

Dominica:

mabizou
red sage

Guatemala:

siete negritos

Other vernacular names

Haiti:

Bonbonye
Bonbonyen
Flè solèy

Guadeloupe:

camomille/mille-fleurs
man bisou

Venezuela:

Cariaquillo, cariaquito

Trinidad and Tobago:

Graterwood = guanatel = kayakeet

Dominica:

Mabizou
red sage o ma bizou

French Guiana:

Rubban

Colombia:

Sugar dish

Geographical distribution

Native to tropical and subtropical America, introduced and naturalised in the tropical and subtropical areas of the Old World.

Botanical description

Shrub of up to 2 m in height, with or without recurved thorns, hispid stems, square in cross section. Opposite or triangularly shaped leaves, oval to oblong, rugose lamina, crenate or serrate margins. Inflorescence with subulate lower bracts; corolla variable in colour from red to orange or yellow and lilac or light purple. Dark purple berries.

Voucher(s)

Girón,197,CFEH

Gimenez,275675,VEN

Delaigue,16,NHTT

Boulogne,TH13,UAG

Boulogne,TB10,UAG

flu

flower, decoction, orally³

flu

aerial parts, syrup or infusion, orally^1,24

lung disease

aerial parts, syrup or infusion, orally^1,24

skin diseases

leaf, infusion, applied locally²

fever

aerial parts, syrup or infusion, orally^1,24

flu

aerial parts, decoction, orally³

The ethanolic extract (95%) from fresh leaves (2 mg/kg), orally in rats after 3 minutes of exposure to sunlight, produced photodermatitis. With 1 g/kg it caused liver toxicity²¹.

The fresh leaves (350 g/animal), orally in cattle, caused general toxic effects²², and in guinea pigs at doses of 2 g/kg²³.

The dried leaves (6 g/kg) orally in rabbits²⁴ and cows²⁵ caused general toxic effects in both cases.

The whole dried plant (4 g/kg) orally in buffalo caused general toxic effects²⁶.

The administration of the whole plant orally to young bulls caused general toxic effects, manifested by weakness, anorexia, constipation, dehydration, photosensitivity and depression²⁷.

Contact with the plant can cause allergic dermatitis in humans²⁸. The leaves contain lantadenes, which are photosensitising²⁹.

Kidney and liver toxicity of the entire plant has been described³⁰.

In the event of accidental intoxication, gastric lavage²⁰ and administration of activated charcoal is recommended³¹.

The leaves contain triterpenes: lantamarone, lantadene A and B; acids: lantanoic, lantic and ursolic acid, among others^8-9; phenylpropanoids: calceolarioside A and E, isonuomioside A, verbascoside¹⁰; flavonoids: camaroside¹¹, pectolinarigenin-7-O- glucoside¹², quercetin derivatives¹³; essential oils: caryophyllene, phellandrene, dipentene, terpineol, geraniol, cineol, linalool, eugenol, furfural¹⁴.

TRAMIL Work¹⁵

The aqueous flower extract (decoction) at a concentration of 1000 µg/ml in vitro showed no antimicrobial activity against Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans, Klebsiella pneumoniae, Mycobacterium smegmatis, Salmonella gallinarum or Escherichia coli.

The ethanolic extract (95%) of leaf and bark (0.1 mg/ml) in vitro

stimulated smooth muscle contraction in guinea pigs¹⁶.

The leaf tincture (0.1 ml/disc) in vitro was inactive against Candida albicans, producing a halo of inhibition of less than 6 mm¹⁷.

Antihemorrhagic¹⁸, antispasmodic and antibiotic activity has been described in the leaves, as well as activity similar to quinine¹⁹.

Lantadene A is attributed with hypotension and hypothermia²⁰.

Pharmacopoeia

Ed.3

References

1. GRAVESON R, 2010

The Plants of Saint Lucia. www.ecotourismstlucia.info/floweringplants/verbenaceae/ lantstri/lantstri.html (31oct2011)

2. SERVISS BE, 2010

Non-native Woody Plants of Arkansas. www.hsu.edu/default.aspx?id=6347 (31oct2011)

3. GIRON L, 1988

Encuesta TRAMIL (Costa atlántica). Centro Mesoamericano de Tecnología CEMAT,

Guatemala, Guatemala.

4. CHARLES C, 1988

TRAMIL survey. Movement for Cultural Awareness MCA, Roseau, Dominica.

5. DELAIGUE J, 2005

TRAMIL survey. UAG & PRDI, Tobago House of Assembly, Scarborough, Tobago.

6. DELENS M, 1990

Encuesta TRAMIL en Barlovento, Edo. Miranda de Venezuela. Centro al Servicio de la Acción Popular CESAP, Caracas, Venezuela.

7. BOULOGNE I, 2009

Enquête TRAMIL, (Terre-de-Bas et Terre-de-Haut) Les Saintes, UAG, Guadeloupe (FWI).

8. SUNDARARAMAIAH T, BAI VV, 1973

Chemical examination of Lantana camara. J Indian Chem Soc 50(9):620.

9. HART NK, LAMBERTON JA, SIOUMIS AA, SUARES H, 1976

New triterpenes of Lantana camara H. A comparative study of the constituents of several taxa. Aust J Chem 29(3):655-671.

10. TAOUBI K, FAUVEL M, GLEYE J, MOULIS C, FOURASTE I, 1997

Phenylpropanoid glycosides from Lantana camara and Lippia multiflora. Planta Med 63(12):192-193.

11. PAN WD, MAI LT, LI YJ, XU XL, YU DQ, 1993

Studies on the chemical constituents of the leaves of Lantana camara. Yao Xue Xue Bao 28(1):35-39.

12. VERMA D, SINGH S, TRIPATHI V, 1997

A rare antibacterial flavone glucoside from Lantana camara. Indian Drugs 34(1):32-35.

13. WOLLENWEBER E, DORR M, MUNIAPPAN R, SIEMS K, 1997

Flavonoid aglycones and triterpenoids from the leaf exudate of Lantana camara and

Lantana montevidensis. Biochem Syst Ecol 25(3):269-270.

14. AHMED Z, EL-MOGHAZY SHOAIB A, WASSEL G, EL-SAYYAD S, 1972

Phytochemical study of Lantana camara. I. Planta Med 21(3):282-288.

15. SOLIS PN, RODRIGUEZ N, ESPINOSA A, GUPTA MP, 2004

Estudio antimicrobiano de algunas plantas TRAMIL con usos en Martinica. Informe TRAMIL. Centro de Investigaciones Farmacognósticas de la Flora Panameña CIFLORPAN, Facultad de Farmacia, Universidad de Panamá, Panamá, Panamá.

16. OCCHIUTO F, CIRCOSTA C, COSTA DE PASQUALE R, 1989

Studies on some medicinal plants on Senegal: effects on isolated guinea pig ileum. J Ethnopharmacol 26(2):205-210.

17. CACERES A, FIGUEROA L, TARACENA A, SAMAYOA B, 1993

Plants used in Guatemala for the treatment of respiratory diseases. 2: Evaluation of activity of 16 plants against gram + bacteria. J Ethnopharmacol 39(1):77-82.

18. WANJARI D, 1983

Antihaemorrhagic activity of Lantana camara. Nagarjun 27(2):40-41.

19. AYENSU E, 1982

Medicinal plants of the West Indies. Algonac, USA: Reference Publications Inc.

20. DUKE JA, 1988

Handbook of medicinal herbs. Boca Raton, USA: CRC Press.

21. AKHTER MH, MATHUR M, BHIDE NK, 1990

Skin and liver toxicity in experimental Lantana camara poisoning in albino rats. Indian J Physiol Pharmacol 34(1):13-16.

22. MORTON JF, 1994

Lantana, or red sage (Lantana camara L.,[Verbenaceae]), notorious weed and popular garden flower; some cases of poisoning in Florida. Econ Bot 48(3):259-270.

23. SHARMA OP, MAKKAR HPS, DAWRA RK, 1982

Biochemical effects of the plant Lantana camara on guinea pig liver mitochondria. Toxicon 20:783-786.

24. SHARMA OP, DAWRA RK, KRISHNA L, MAKKAR HPS, 1988

Toxicity of Lantana (Lantana camara L) leaves and isolated toxins to rabbits. Vet Hum Toxicol 30(3):214-218.

25. DWIVEDI SK, SHIVNANI GA, JOSHI HC, 1971

Clinical and biochemical studies in Lantana poisoning in ruminants. Indian J Anim Sci 41(10):948-953.

26. HARI R, SHIVNANI GA, HOSHI HC, 1974

Efficacy of certain drug treatment in Lantana poisoning in Buffalo calves in relation to biochemical changes. Indian J Anim Sci 43(9):829-833.

27. FOURIE N, VAN DER LUGT JJ, NEWSHOLME SJ, NEL PW, 1990

Acute Lantana camara toxicity in cattle. J South African Vet Assoc 58(4):173-178.

28. SHARMA VK, KAUR S, 1987

Contact dermatitis due to plants in Chandigarh. Indian J Dermatol Venereol Leprol 53(1):26-30.

29. SHARMA OP, DAWRA RK, MAKKAR HP, 1989

Toxicity of isolated lantana (Lantana camara L.) constituents to male and female guinea pigs. Vet Hum Toxicol 31(1):10-13.

30. NAOUAR-LABOUP M, 1984

Connaissance sur des Verbénacées: Lantana camara L., espèce hépatotoxique. Constituants chimiques du genre Clerodendron. Doctorat d’Etat n°98, mention pharmacie. Université de Toulouse, France.

31. PASS MA, STEWART C, 1984

Administration of activated charcoal for the treatment of Lantana poisoning of sheep and cattle. J Appl Toxicol 4(5):267-269.

Warnings

According to the information available:

The use of the aerial parts for fever, flu, lung and skin diseases is classified as TOXIC (TOX).

Given the toxicity of the aerial parts of this plant, its oral and topical use is discouraged, regardless of the therapeutic qualities it offers.

In the event of intoxication by ingestion, seek medical assistance.

Disclaimer

The information provided is for educational purposes only for the benefit of the general public and health professionals. It is not intended to take the place of either the written law or regulations. Since some parts of plants could be toxic, might induce side effects, or might have interactions with certain drugs, anyone intending to use them or their products must first consult with a physician or another qualified health care professional. TRAMIL has no responsibility whatsoever towards the user for any decision, action or omission made in relation to the information contained in this Pharmacopoeia.

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Lantana camara

Vernacular names

Venezuela:

Trinidad and Tobago:

Dominica:

Guatemala:

Haiti:

Guadeloupe:

Venezuela:

Trinidad and Tobago:

Dominica:

French Guiana:

Colombia:

Geographical distribution

Botanical description

Voucher(s)

Pharmacopoeia

References

Warnings

Disclaimer