Hyptis atrorubens

Scientific name: Hyptis atrorubens Poit.

Botanical family: LAMIACEAE

Vernacular names

(In territories with significant traditional TRAMIL use)

Martinique:

makouza

Other vernacular names

Martinique:

makouza

Geographical distribution

Antilles, tropical America and tropical

Botanical description

Herbaceous creeping or erect, stems up to 3 m, slightly downy/hirsute. Ovate-oblong leaves of 2 to 4 cm in length and 1.2 to 1.5 cm in width, both pubescent surfaces with resinous spots, crenate-serrate margins, narrowly margined petioles.
Flowers in axillary heads, semiglobose, 1 cm in diameter, with a peduncle up to 2.5 cm; bracts ovate or elliptic, 4 to 6 mm, hirsute and ciliate; calyx 3 to 4 mm, teeth equal; corolla white or white-greenish, 4 to 5 mm; fruits, nuts 0.7 to 1 mm in length, glabrous.

Voucher(s)

Longuefosse&Nossin,57,HAVPM

For gratel:
Crush 30 grams of fresh leaves and add them to each litre of water, leave to settle for 10 minutes before rubbing the leaves over the affected parts in the bath. Repeat 2 or 3 times a day.

Preparations must never be stored for more than 24 hours, even if refrigerated.

According to the information available:

The use for gratel (rash with or without pruritus) is classified as REC based on the significant traditional use documented in TRAMIL surveys and toxicity studies.

No information is available in the scientific literature for validation of the topical use of leaf maceration for gratel.

All topical application must follow strict hygiene measures in order to prevent contamination or additional infection.

If deterioration is observed in the patient or the condition persists for more than 5 days in adults and 3 days in children, seek medical attention.

No data are available to recommend their medicinal use during pregnancy and breastfeeding.

TRAMIL Work⁵
The dried leaves, macerated in water for 24 hours, crushed (patch with 0.6 g/6 cm² of skin/4 hours), were applied topically in New Zealand albino rabbits (4 males), Draize’s model of acute dermal irritability, the patch was removed after 3 hours and the area was washed. Erythema and oedema readings were taken at 1 and 24, 48 and 72 hours, showing an index of 0.00, which is classified as non-irritant.

There is no information available documenting the safety of medicinal use in children, during pregnancy or breastfeeding.

TRAMIL Work²
The dried leaf extracts (decoction and maceration at 30% and tinctures at 30, 50 and 80% in ethanol) showed the presence of alkaloids, lactic compounds, triterpenes and steroids, flavonoids, tannins, reducing sugars, saponins and anthocyanidins and the absence of quinones in the decoction.

Preliminary phytochemical selection (whole plant)³.

alkaloids:	+	saponosides	+
steroids, terpenoids:	-	quinones	-
flavonoid pigments:	+	tannins	-

TRAMIL Work⁴

The aqueous maceration (50%) of dried leaves did not show activity in vitro against Staphylococus aureus
(ATCC 29737) or Candida albicans (ATCC 10231).

Pharmacopoeia

Ed.3

References

1 LONGUEFOSSE JL, NOSSIN E, 1990-95
Enquête TRAMIL. Association pour la valorisation des plantes médicinales de la Caraïbe AVPMC, Fort de France, Martinique.
2 MOREJON Z, NOSSIN E, MORON FJ, 2011
Tamizaje fitoquímico de cuatro extractos hojas secas de Hyptis atrorubens. Informe TRAMIL. Facultad de Ciencias Médicas “Dr. Salvador Allende”, Laboratorio Central de
Farmacología, La Habana, Cuba.
3 GRENAND P, MORETTI C, JACQUEMING H, 1987
Pharmacopées traditionelles en Guyane. Paris, France : Editions ORSTOM/IRD, p478.
4 BOUCOURT E, MARTINEZ MJ, MOREJON Z, LOPEZ M, GARCIA AI, MORON
FJ, 2011
Ausencia del efecto antimicrobiano de la maceración acuosa de hojas secas de Hyptis atrorubens Poit. Informe TRAMIL. Facultad de Ciencias Médicas “Dr. Salvador Allende”, Laboratorio Central de Farmacología, La Habana, Cuba.
5 MARTINEZ MJ, LOPEZ M, NOSSIN E, MOREJON Z, BOUCOURT E, FUENTES
V, MORON F, 2007
Irritabilidad dérmica primaria de partes aéreas secas de Hyptis atrorubens Poit. Informe TRAMIL. Laboratorio Central de Farmacología, Facultad de Ciencias Médicas “Dr. Salvador Allende”, La Habana, Cuba.

Disclaimer

The information provided is for educational purposes only for the benefit of the general public and health professionals. It is not intended to take the place of either the written law or regulations. Since some parts of plants could be toxic, might induce side effects, or might have interactions with certain drugs, anyone intending to use them or their products must first consult with a physician or another qualified health care professional. TRAMIL has no responsibility whatsoever towards the user for any decision, action or omission made in relation to the information contained in this Pharmacopoeia.

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Hyptis atrorubens

Vernacular names

Martinique:

Martinique:

Geographical distribution

Botanical description

Voucher(s)

Pharmacopoeia

References

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