Cissampelos pareira

Scientific name: Cissampelos pareira L.

Synonym: Cissampelos cordata Ruiz

Botanical family: MENISPERMACEAE

Vernacular names

(In territories with significant traditional TRAMIL use)

Haiti:

pat chwal

Other vernacular names

Haiti:

Fèy kè
Pat chwal

St Vincent and Grenadines:

Grave yard

Geographical distribution

Widely distributed in the tropical regions of the world.

Botanical description

Herbaceous climbing plant, pubescent to tomentose. Suborbicular or ovate leaves, 3.5 to 10 cm, rounded to emarginated, often peltate. Staminate inflorescence in corymbs up to 7 cm born in the axils of the leaves; green female flowers in racemes of up to 8 cm. Subglobose drupe (fruit), reddish from 3.5 to 4.5 mm in diameter.

Voucher(s)

Voltaire,256,SOE

stomach pain

leaf, decoction, orally¹

For stomach pain:

prepare a decoction with 10 grams of fresh leaves in 3 cups (750 millilitres) of water, boil for 10 minutes in a covered vessel.
Leave to cool, strain (filter) and drink 1 cup 3 times a day.

Preparations must never be stored for more than 24 hours, even if refrigerated.

According to the information available:

The use for stomach pain is classified as REC based on the significant traditional use documented in the TRAMIL surveys, the toxicity and validation studies, and the scientific information published.

If deterioration is observed in the patient or if the stomach pain persists for more than 3 days, seek medical attention.

Not for use during pregnancy, breastfeeding or in children under 7 years of age.

TRAMIL Work¹¹
The aqueous decoction from dried leaves (1-5 g/kg) orally in mice did not cause death.

The minimum acute toxic dose of the hydroalcoholic (95%) and aqueous leaf and stem extracts via the intraperitoneal route in mice was 0.1 ml/animal¹⁰.

Three whole plant extracts were inactive in in vitro cytotoxicity tests¹² .

The alkaloids in the plant caused bradycardia and uterine relaxation, in in vitro models¹³.

There is no information available documenting the safety of medicinal use in children, during pregnancy or breastfeeding.

The leaf contains isoquinoline alkaloids: (-) curine, cycleanine,
hayatine, hayatinine and carbohydrates: D-quercitol^2-3.

The whole plant contains isoquinoline alkaloids: pareirubrine⁴, cissampareine⁵

The aerial parts contain polyphenolic compounds such as 2-(4- hydroxy-3-methoxyphenyl)-7-(4-methoxyphenyl)-6-(2-hydroxy- 4,6-dimethoxybenzoyl)-furan[3,2-g]benzopyran-4-one⁶ , flavonoids and tannins⁷.

TRAMIL Work⁸
The aqueous leaf extract (50%, 30 mg/ml) in a rat ileum model significantly decreased the contractions experimentally produced by acetylcholine.

The hydroalcoholic leaf extract induced antibacterial activity against Escherichia coli and Staphylococcus aureus⁹.

The aqueous leaf and stem extract, (0.1 ml/l) in the guinea pig ileum model caused a spasmolytic response; the hydroalcoholic extract (95%, 0.33 ml/l) in the rabbit smooth muscle model and in the guinea pig ileum model showed relaxant activity¹⁰.

Pharmacopoeia

Ed.3

References

1 WENIGER B, ROUZIER M, 1986
Enquête TRAMIL. Service Oecuménique d’Entraide SOE, Port au Prince, Haïti.

2 KUPCHAN SM, PATEL AC, FUJITA E, 1965
Tumor inhibitors VI. Cissampareine, new cytotoxic alkaloid from Cissampelos pareira, cytotoxicity of benzylisoquinoline alkaloids. J Pharm Sci 54:580.

3 SINGH A, DUGGAL S, SINGH J, KATEKHAY S, 2010
An inside preview of ethnopharmacology of Cissampelos pareira Linn. International J of Biological Technology 1(1):114-120.

4 BHATNAGAR AK, BHATTACHARJI S, POPLI SP, 1968
Nuclear magnetic resonance spectrum of cycleanine. Indian J Chem 6:125.

5 ANWER F, POPLI SB, SRIVASTAVA RM, KHARE MP, 1968
Studies in medicinal plants. Part III. Protoberberine alkaloids from the roots of
Cissampelos pareira. Experientia 24:999.

6 RAMIREZ I, CARABOT A, MELENDEZ P, CARMONA J, JIMENEZ M, PATEL AV, CRABB TA, BLUNDEN G, CARY PD, CROFT SL, COSTA M, 2003 Cissampeloflavone, a chalcone-flavone dimer from Cissampelos pareira. Phytoche- mistry 64(2):645–647.

7 MOJAB F, KAMALINEJAD M, GHADERI N, VAHIDIPOUR HR, 2003
Screening of some species of Iranian plants. Iranian J of Pharmaceutical Research: 77-82.

8 HERRERA J, 1994
Determinación de actividades biológicas de vegetales utilizados en medicina
tradicional. Informe TRAMIL. Laboratorio de Fitofarmacología, Departamento de Farmacología, Facultad de Salud, Universidad del Valle, Cali, Colombia.

9 GEORGE M, PETALAI K, 1949
Investigations on plant antibiotics. Part IV. Further search for antibiotic substances in Indian medicinal plants. Indian J Med Res 37:169-181.

10 FENG PC, HAYNES LJ, MAGNUS KE, PLIMMER JR, SHERRAT HSA, 1962
Phamacological screening of some West Indian medicinal plants. J Pharm Pharmacol 14:556-561.

11 SARAVIA A, 1992
Toxicidad de Cissampelos pareira. Informe TRAMIL. Universidad de San Carlos, Guatemala, Guatemala. TRAMIL VI, Basse Terre, Guadeloupe, UAG/enda-caribe.

12 CHAPUIS J, SORDAT B, HOSTETTMANN K, 1988
Screening for cytotoxic activity of plants used in traditional medicine. J
Ethnopharmacol 23(2/3):273-284.

13 ROY P, 1952
A preliminary note on the pharmacological action of the total alkaloids isolated from Cissampelos pareira. Indian J Med Res 40:95.

Disclaimer

The information provided is for educational purposes only for the benefit of the general public and health professionals. It is not intended to take the place of either the written law or regulations. Since some parts of plants could be toxic, might induce side effects, or might have interactions with certain drugs, anyone intending to use them or their products must first consult with a physician or another qualified health care professional. TRAMIL has no responsibility whatsoever towards the user for any decision, action or omission made in relation to the information contained in this Pharmacopoeia.

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Cissampelos pareira

Vernacular names

Haiti:

Haiti:

St Vincent and Grenadines:

Geographical distribution

Botanical description

Voucher(s)

Pharmacopoeia

References

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