Capraria biflora

Scientific name: Capraria biflora L.

Botanical family: SCROPHULARIACEAE

Vernacular names

(In territories with significant traditional TRAMIL use)

Trinidad and Tobago:

ditay paye, titi paye

Venezuela:

fregosa

Guadeloupe:

té péyi
té péyi

Other vernacular names

Trinidad and Tobago:

ditay paye = titi paye

Martinique:

dité péyi, thé-pays

esclaviosa

Venezuela:

fregosa

Dominica:

goat weed the ' des

Guadeloupe:

te pays
thé-pays (té péyi)

Geographical distribution

Widely distributed in tropical America.

Botanical description

Herbaceous or subshrub of up to 1 m in height. Oblanceolate or oblong leaves, 1 to 9 cm, acute, sawn in the upper half; sessile or short petioles. Flowers solitary, axillary or in pairs, 4 to 6 mm linear-lanceolate sepals, 1 cm corolla, white. Oval to oval-ovoid capsule, 5 to 6 mm.

Voucher(s)

J.Fournet, 4213, GUAD

Delens, 264228-04, VEN
Delaigue, 4, NHTT

For all uses:
prepare a decoction or infusion with 30 grams of fresh leaves (or aerial parts) in 4 cups (1 litre) of water. For decoctions boil for 10-15 minutes in a covered container; for the infusion add the boiling water to the 30 grams of fresh leaves (or aerial parts), cover, let cool for 5 minutes, strain (filter) and drink 1 cup 3 times
a day.

Preparations must never be stored for more than 24 hours, even if refrigerated.

According to the information available:

The use for wind, flu, intestinal parasites and biliary problems is classified as REC based on the significant traditional use documented in the TRAMIL surveys and the toxicity studies.

Not for use during pregnancy, breastfeeding or in children under 8 years of age.

TRAMIL Work¹¹

The aqueous leaf extract (decoction 4.45% total solids) freeze-dried, orally (2 ml/100 g body weight) single dose in rats (female and male), in the OECD acute toxic class model, did not cause death or evident signs of toxicity in the 14 days of observation, and no organ damage was evident in the necropsy.

The aqueous extract (decoction 10% weight/volume) freeze-dried, dried leaf, orally (2 g/kg) single dose, in Swiss mice (25- 30 g) 10 males and 10 females, did not cause evident signs of toxicity or changes in the organs¹².

No information is available to recommend use during pregnancy, breastfeeding or in children.

TRAMIL Work⁵
Preliminary phytochemical study (aerial parts)

alkaloids	-
saponins	+
flavonoids(absence of flavonols and flavanones)	++
quiones	traces
tannins	+++
steroids, terpenoids	+

The plant has the flavonoids: biflorin⁶, the aerial parts have the flavonoids: harpagide and 8-O-benzoylharpagide (caprarioside⁷) and the sesquiterpenes: caprariolides A (00.001%), B (00.00005%), C (00.00004%) and D (00.00014%)⁸.

TRAMIL Work⁹
The aqueous extract (decoction 1.02 % of total solids) from freeze-dried leaves, taken orally (2.77 g of dry material/50 ml of water, equivalent to decoction 30% of fresh material; yield 1.02% of total solids) for 4 days, in male OF1 mice (25-30 g), 10 animals/group, in an intestinal transit model with 10% activated
carbon marker (0.1 ml/10 g of body weight), did not significantly modify intestinal transit.

The aqueous extract from dried leaves (50-200 mg/kg), in mouse models of acetic acid and hot plate-induced pain, showed an analgesic effect¹⁰ , attributed to harpagide and 8-O- benzoylharpagide (or caprarioside), present in the aerial parts⁷.

Pharmacopoeia

Ed.3

References

1 BALZ E, BOYER A, BURAUD M, 2007
Enquête TRAMIL à Marie-Galante. U. Bordeaux 3, U. Paris XI Chatenay-Malabry, UAG, Guadeloupe.

2 DELENS M, 1990
Encuesta TRAMIL en Barlovento, Edo. Miranda de Venezuela. Centro al Servicio de la Acción Popular CESAP, Caracas, Venezuela.

3 ZAMBRANO LE, 2007
Encuesta TRAMIL en Guareguare, Miranda. UCV, Caracas, Venezuela.

4 EDOUARD JA, 1992
Enquête TRAMIL. Lycée agricole, Baie-Mahault, Guadeloupe.

5 SYLVESTRE M, LEGAULT J, PICHETTE A, 2003
Tri phytochimique de plantes de la liste TRAMIL. Laboratoire d’Analyse et de Séparation des Essences Végétales, Université du Québec à Chicoutimi, Québec, Canada.

6 DUKE J, 1992
Handbook of phytochemical constituents of GRAS Herbs and other economic plant. Boca Ratón, USA: CRS Press.

7 HEINRICH M, RIMPLER H, 1989
Harpagide and 8-O-Benzoylharpagide from the Mixe medicinal plant Capraria biflora. Planta Med 55(7):626.

8 COLLINS DO, GALLIMORE WA, REYNOLDS WF, WILLIAMS LA, REESE PB, 2000
New skeletal sesquiterpenoids, caprariolides A-D, from Capraria biflora and their insecticidal activity. J Nat Prod 63(11):1515-1518.

9 VICTORIA MC, MARTINEZ I, BOULOGNE I, BRITO G, MORON F, 2012
Ausencia de actividad sobre el tránsito intestinal de la decocción de hoja liofilizada de Capraria biflora L en ratones. Trabajo TRAMIL. Laboratorio Central de Farmacología, Facultad de Ciencias Médicas “Dr. Salvador Allende”, La Habana, Cuba.

10 ACOSTA SL, MURO LV, SACERIO AL, PENA AR, OKWEI SN, 2003
Analgesic properties of Capriaria biflora leaves acqueous extract. Fitoterapia 74(78):686-688.

11 LOPEZ M, BOULOGNE I, BACALLAO Y, MARTINEZ MJ, MORON F, 2012
Recherche d’activité toxique aiguë de la décoction de la feuille lyophilisée de Capraria biflora L. Travail TRAMIL. Laboratorio Central de Farmacología, Facultad de Ciencias Médicas “Dr. Salvador Allende”, La Habana, Cuba.

12 ACOSTA SL, MURO LV, LOPEZ SACERIO AR, MONTEAGUDO GL, REINOSO
PENA A, OKWEI SN, 2003
Efecto antiinflamatorios de un extracto de Capraria biflora L. Acta farmaceutica bonaerense 22(1):53-55.

Disclaimer

The information provided is for educational purposes only for the benefit of the general public and health professionals. It is not intended to take the place of either the written law or regulations. Since some parts of plants could be toxic, might induce side effects, or might have interactions with certain drugs, anyone intending to use them or their products must first consult with a physician or another qualified health care professional. TRAMIL has no responsibility whatsoever towards the user for any decision, action or omission made in relation to the information contained in this Pharmacopoeia.

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Capraria biflora

Vernacular names

Trinidad and Tobago:

Venezuela:

Guadeloupe:

Trinidad and Tobago:

Martinique:

Venezuela:

Dominica:

Guadeloupe:

Geographical distribution

Botanical description

Voucher(s)

Pharmacopoeia

References

Disclaimer